Articles

Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells

Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport.

Authors: Bing Sun, Rongmei Qu, Tingyu Fan, Yuchao Yang, Xin Jiang, Asmat Ullah Khan, Zhitao Zhou, Jingliao Zhang, Kuanhai Wei, Jun Ouyang and Jingxing Dai

Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival

The expression signature of deregulated long non-coding RNAs (lncRNAs) and related genetic variants is implicated in every stage of tumorigenesis, progression, and recurrence. This study aimed to explore the a...

Authors: Shahad W. Kattan, Yahya H. Hobani, Sameerah Shaheen, Sara H. Mokhtar, Mohammad H. Hussein, Eman A. Toraih, Manal S. Fawzy and Hussein Abdelaziz Abdalla

Molecular interactions of miR-338 during tumor progression and metastasis

Cancer, as one of the main causes of human deaths, is currently a significant global health challenge. Since the majority of cancer-related deaths are associated with late diagnosis, it is necessary to develop...

Authors: Meysam Moghbeli

Relationship between miR-378c and YY1 expression in patients with gastric cancer and the clinicopathological features

The purpose of this study was to explore the clinical value of miR-378c and its target gene YY1 in gastric cancer.

Authors: Lei Zhang, Lei Zou and Peng Sun

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell surv...

Authors: Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn and Rafal Bartoszewski

Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease

Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation...

Authors: Marcin Woźniak, Christian J. Konopka, Agata Płoska, Jamila Hedhli, Anna Siekierzycka, Maciej Banach, Rafal Bartoszewski, Lawrence W. Dobrucki, Leszek Kalinowski and Iwona T. Dobrucki

Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating d...

Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang and Lining Wei

Retraction Note to: Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s11658-021-00252-1

Authors: Yan Hao, Haitao Yuan and Houzhi Yu

The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation

NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4⁺ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4⁺IL22⁺IFNγ⁻IL17A⁻) cells are a subgroup o...

Authors: Chong Zeng, Zhongbao Shao, Zibo Wei, Jie Yao, Weidong Wang, Liang Yin, Huixian YangOu and Dan Xiong

ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells

ZNF674-AS1, a recently characterized long noncoding RNA, shows prognostic significance in hepatocellular carcinoma and glioma. However, the expression and function of ZNF674-AS1 in non-small cell lung cancer (...

Authors: Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin and Liangcheng Zheng

Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns

The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological dise...

Authors: Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schiöth and Robert Fredriksson

Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis

miRNAs are well known to be gene repressors. A newly identified class of miRNAs termed nuclear activating miRNAs (NamiRNAs), transcribed from miRNA loci that exhibit enhancer features, promote gene expression ...

Authors: Emmanuel Odame, Yuan Chen, Shuailong Zheng, Dinghui Dai, Bismark Kyei, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li and Hongping Zhang

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppre...

Authors: Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu and Xuerong Chen

Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcu...

Authors: Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu and Siqian Wang

Beyond K48 and K63: non-canonical protein ubiquitination

Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly regulated proteolysis, ubiquitination is now regard...

Authors: Michal Tracz and Wojciech Bialek

In vitro differentiation of W8B2⁺ human cardiac stem cells: gene expression of ionic channels and spontaneous calcium activity

Human cardiac stem cells expressing the W8B2 marker (W8B2⁺ CSCs) were recently identified and proposed as a new model of multipotent CSCs capable of differentiating into smooth muscle cells, endothelial cells and...

Authors: Oualid Ayad, Zeina R. Al Sayed, Stéphane Sebille, Christophe Magaud, Charles-Albert Chapotte-Baldacci, Christophe Jayle, Jean-François Faivre, Nathalie Gaborit, Aurélien Chatelier and Patrick Bois

MicroRNA-296-5p inhibits cell metastasis and invasion in nasopharyngeal carcinoma by reversing transforming growth factor-β-induced epithelial–mesenchymal transition

To explore the effect of miR-296-5p on the metastasis of nasopharyngeal carcinoma (NPC) cells and investigate the underlying mechanism.

Authors: Meihui Chen, Chen Chen, Haiqing Luo, Jing Ren, Qiuqin Dai, Wenjia Hu, Keyuan Zhou, Xudong Tang and Xiangyong Li

The nuclear receptor 4A family members: mediators in human disease and autophagy

The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involveme...

Authors: Liqun Chen, Fengtian Fan, Lingjuan Wu and Yiyi Zhao

hsa_circ_0006916 promotes hepatocellular carcinoma progression by activating the miR-337-3p/STAT3 axis

Circular RNAs (circRNAs) are thought to be involved in the development of various malignancies. The expression and function of hsa_circ_0006916, a newly identified circRNA, in hepatocellular carcinoma remain u...

Authors: Xiao-Yong Zhou, Hui Yang, Yang-Qiu Bai, Xiu-Ling Li, Shuang-Yin Han and Bing-Xi Zhou

Obituary: in memory of Professor Tadeusz Chojnacki (1932–2020)

Authors: Ewa Swiezewska and Anna Chojnacka

Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT

Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in pulmonary arterial hypertension (PAH). Serotonin (5-hydroxytryptamine, 5-HT) can induce abnormal proliferation of P...

Authors: Ying Zhang, Yongbin Chen, Guo Chen, Yingling Zhou, Hua Yao and Hong Tan

Arsenic trioxide as a novel anti-glioma drug: a review

Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regu...

Authors: Yi Fang and Zhen Zhang

Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1

Long intergenic non-protein coding RNA00665 (LINC00665) plays a crucial tumorigenic role in many cancers, such as gastric cancer and lung adenocarcinoma. However, its role and mechanism of action in the progre...

Authors: Minhao Lv, Qixin Mao, Juntao Li, Jianghua Qiao, Xiuchun Chen and Suxia Luo

Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth

Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, the molecular mechanism of rapid antler growth remains to be elucidated. The a...

Authors: Baojin Yao, Chaonan Wang, Zhenwei Zhou, Mei Zhang, Daqing Zhao, Xueyuan Bai and Xiangyang Leng

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...

Authors: Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp and Borivoj Vojtesek

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown...

Authors: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka and Takashi Iwamoto

Specific functions of Exostosin-like 3 (EXTL3) gene products

Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the anim...

Authors: Shuhei Yamada

Effects of HPV16 E6 protein on Daxx-induced apoptosis in C33A cells

Daxx is a highly conserved nuclear protein with an important role in transcription, apoptosis and other cell processes. We investigated the role of HPV16 E6 in Daxx-induced apoptosis through their interactions...

Authors: Shuangyang Tang, Shuang Ding, Lan Yu, Haiyan Shen, Yanping Wan and Yimou Wu

Do ABC transporters regulate plasma membrane organization?

The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical prope...

Authors: Ambroise Wu, Karolina Wojtowicz, Stephane Savary, Yannick Hamon and Tomasz Trombik

Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1

Rhomboid domain containing 1 (RHBDD1) plays a crucial role in tumorigenesis. Silibinin, which is a natural extract from milk thistle, has shown anti-tumor effects against various tumors. Here, we investigate w...

Authors: Suyan Xu, Hongyan Zhang, Aifeng Wang, Yongcheng Ma, Yuan Gan and Guofeng Li

The usefulness of lactate dehydrogenase measurements in current oncological practice

One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associat...

Authors: Agata Forkasiewicz, Maja Dorociak, Kamilla Stach, Piotr Szelachowski, Renata Tabola and Katarzyna Augoff

LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis

Recent studies have revealed that dysregulated expression of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (lncRNA NNT-AS1) is associated with cell tumorigenicity in non-small ce...

Authors: Jing Ma, Guanbin Qi and Lei Li

Asiaticoside inhibits TGF-β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5

Peritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). Peritoneal mesothelial cells (PMCs), the first barrier of the peritoneum, play an important role in maintaining structure...

Authors: Junyi Zhao, Jun Shi, Yun Shan, Manshu Yu, Xiaolin Zhu, Yilin Zhu, Li Liu and Meixiao Sheng

On the physiological and cellular homeostasis of ascorbate

Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well...

Authors: Magdalena Przybyło and Marek Langner

Role of angiotensin-converting enzyme in myeloid cell immune responses

Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor. Because of it...

Authors: Duo-Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan-Duodu, Ellen A. Bernstein, Jorge F. Giani, Kenneth E. Bernstein and Zakir Khan

Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2

Dysregulation of the proliferation and migration of vascular smooth muscle cells (VSMCs) is a crucial cause of atherosclerosis. MiR-637 exerts an antiproliferative effect on multiple human cells. Its impact on...

Authors: Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Jingyu Yang and Qin Qin

LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5

Long non-coding RNA (lncRNA) as a widespread and pivotal epigenetic molecule participates in the occurrence and progression of malignant tumors. DRAIC, a kind of lncRNA whose coding gene location is on 15q23 c...

Authors: Zheng Zhang, Xiaoxuan Hu, Jia Kuang, Jinmao Liao and Qi Yuan

Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response

Adoptive T-cell therapy (ACT) using autologous tumor-reactive T lymphocytes has considerable potential for cancer immunotherapy. In ACT, T cells are isolated from cancer patients and then stimulated and expand...

Authors: Salman Bagheri, Elmira Safaie Qamsari, Mehdi Yousefi, Farhad Riazi-Rad and Zahra Sharifzadeh

MicroRNA-186-5p serves as a diagnostic biomarker in atherosclerosis and regulates vascular smooth muscle cell proliferation and migration

MicroRNA dysregulation occurs in many human diseases, including atherosclerosis. Here, we examined the serum expression and clinical significance of miR-186-5p in patients with atherosclerosis, and explored it...

Authors: Bin Sun, Qingtao Cao, Meng Meng and Xiaolong Wang

The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells

Oxidative stress results in cell apoptosis/death and plays a detrimental role in disease development and progression. Stressors alter the miRNA expression profile and miRNAs play a role in the cell response to...

Authors: Duo Zhao, Hao Zheng, Adam Greasley, Fengjun Ling, Qinfeng Zhou, Bowen Wang, Tiffany Ni, Ishita Topiwala, Cuilin Zhu, Tina Mele, Kexiang Liu and Xiufen Zheng

Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion

Cervical cancer remains the second leading cause of mortality in women in developing countries. While surgery, chemotherapy, radiotherapy, and vaccine therapy are being applied for its treatment, individually ...

Authors: Chenglai Xia, Zhihong He and Yantao Cai

TCF 4 tumor suppressor: a molecular target in the prognosis of sporadic colorectal cancer in humans

A huge array of function is played by the Wnt/β-catenin signaling pathway in development by balancing gene expression through the modulation of cell-specific DNA binding downstream effectors such as T-cell fac...

Authors: Mumtaz Anwar, Pooja Malhotra, Rakesh Kochhar, Alka Bhatia, Akhtar Mahmood, Rajinder Singh and Safrun Mahmood

The role of phosphatidylserine recognition receptors in multiple biological functions

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis. Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase-dependent apoptosis, which in ...

Authors: Mehri Bemani Naeini, Vanessa Bianconi, Matteo Pirro and Amirhossein Sahebkar

MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

Non-small lung cancer (NSCLC), with a poor 5-year survival rate (16%), is the major type of lung cancer. Metastasis has been identified as the main factor that leads to NSCLC therapy failure. MiR-206 is a meta...

Authors: Ming Liao and Lijun Peng

LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis

Pulmonary arterial hypertension (PAH) is often characterized by cell proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). LncRNA cancer susceptibility candidate 2 (CASC2) has been re...

Authors: Yan Han, Yuhao Liu, Chaokuan Yang, Chuanyu Gao, Xiaoyan Guo and Jiangtao Cheng

RETRACTED ARTICLE: Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3

MiR-483-5p was recently identified as a risk factor in the early stages of acute myocardial infarction (AMI) patients. Here, we further investigated how miR-483-5p affects cardiomyocyte apoptosis and oxidative...

Authors: Yan Hao, Haitao Yuan and Houzhi Yu

miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/β-catenin signaling

It has been shown that miR-144-3p regulates cell proliferation, apoptosis, migration and invasion in various cancers. However, the function and expression of miR-144-3p in colorectal cancer (CRC) remained obsc...

Authors: Naihui Sun, Liang Zhang, Chongguang Zhang and Yuan Yuan

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their in...

Authors: Sylwia Bartoszewska and James F. Collawn

Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells

High levels of the post-translational modification O-GlcNAcylation (O-GlcNAc) are found in multiple cancers, including bladder cancer. Autophagy, which can be induced by stress from post-translational modifica...

Authors: Lu Jin, Feng Yuan, Guangcheng Dai, Qiu Yao, Han Xiang, Lixia Wang, Boxin Xue, Yuxi Shan and Xiaolong Liu

MicroRNA-125b exerts antitumor functions in cutaneous squamous cell carcinoma by targeting the STAT3 pathway

MicroRNA-125b (miR-125b) is downregulated in human cutaneous squamous cell carcinoma (CSCC). However, its function in CSCC has yet to be extensively explored. Here, we analyze the relationship between signal t...

Authors: Ke Tian, Wanggen Liu, Jing Zhang, Xiaoyi Fan, Jingyuan Liu, Nan Zhao, Chunxia Yao and Guoying Miao