Fig. 5

Up-regulation of ATF3 restrained the activation of Nrf2/Keap1/xCT signaling in SGC7901/DDP cells. A, B Protein expression of Nrf2, Keap1 and xCT was analyzed in SGC7901 and SGC7901/DDP cells. Image J software was used to quantify the density of the bands. C, D After transfection with ATF3 plasmids, activation of Nrf2/Keap1/xCT signaling was detected in SGC7901/DDP cells under cisplatin conditions. *P < 0.05. **P < 0.01